EDUKASI GANGGUAN SARAF TEPI AKIBAT OBAT KEMOTERAPI PADA PASIEN POLI ONKOLOGI RUMAH SAKIT UMUM DAERAH (RSUD) PROVINSI NUSA TENGGARA BARAT
DOI:
https://doi.org/10.29303/abdiinsani.v11i2.1522Keywords:
Education, Peripheral Neuropathy, Chemotherapy, OncologyAbstract
Peripheral neuropathy is a disorder of peripheral nerve fibres secondary to various pathological processes such as diabetes mellitus, vitamin deficiencies or drugs such as chemotherapy regimen. Clinical symptoms include motor, sensory and autonomic disorders. Cancer patients undergoing chemotherapy are susceptible to experiencing symptoms of peripheral neuropathy caused by anatomical changes (such as distal axonal degeneration) or physiological changes. So, the education of regarding peripheral neuropathy is needed in patients with chemotherapy. This community service activity was conducted in the Oncology Building at West Nusa Tenggara Province General Hospital. Implementing activities regarding education on peripheral nerve disorders due to chemotherapy drugs is carried out by providing pretests, educational materials, post-tests and discussions. In the pretest activity, many participants were still unaware of peripheral nerve disorders due to chemoteraphy side effects. In the post-test, the knowledge score was above average (100%) regarding peripheral nerve disorders due to chemoterapy side effects. This shows an increase in the understanding of the side effects of chemotherapy in oncology outpatients clinic at West Nusa Tenggara Province General Hospital
Downloads
References
Brzeziński, K. (2012). Chemotherapy-induced polyneuropathy. Part I. Pathophysiology. Contemporary Oncology, 16(1), 72. https://doi.org/10.5114/WO.2012.27341
Dobson, J.L., McMillan J., & Li, L. (2014). Benefits of exercise intervention in reducing neuropathic pain. Front Cell Neurosci 8:102. doi: 10.3389/fncel.2014.00102.
Dorsey, S. G., Kleckner, I. R., Barton, D., Mustian, K., O’Mara, A., St Germain, D., Cavaletti, G., Danhauer, S. C., Hershman, D. L., Hohmann, A. G., Hoke, A., Hopkins, J. O., Kelly, K. P., Loprinzi, C. L., McLeod, H. L., Mohile, S., Paice, J., Rowland, J. H., Salvemini, D., & Janelsins, M. C. (2019). The National Cancer Institute Clinical Trials Planning Meeting for Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy. Journal of the National Cancer Institute, 111(6), 531–537. https://doi.org/10.1093/JNCI/DJZ011
Gadgil, S., Ergün, M., Heuvel, S. A., Wal, S. E., Scheffer, G. J., & Hooijmans, C. R. (2019). A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN). PloS One, 14(8). https://doi.org/10.1371/JOURNAL.PONE.0221787
Hammi, C., Yeung B. (2022). Neuropathy. [Updated 2022 Oct 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542220/
Hanum, A. S., & Kurniawan S. N. (2023). Drug induced neuropathy. Journal of Pain, Headache and Vertigo, 2023.4,6-45. DOI:10.21776/ub.jphv.2023.004.02.3
Hunaifi, I., Harahap, H. S., Anggoro, J., Asmara, I. G. Y., Lestari, R., & Suryani, D. (2019). Edukasi Deteksi Dini Stroke Pada Komunitas Diabetes Di Kota Mataram aterosklerosis . Perubahan awal dari endotel merupakan kunci terjadinya aterosklerosis . menjadi gejala pada sirkulasi otak sisi anterior dan sirkulasi otak sisi poster. Jurnal Gema Ngabdi 1(1), 1–6.
Ibrahim, E. Y., & Ehrlich, B. E. (2020). Prevention of Chemotherapy-Induced Peripheral Neuropathy: A Review of Recent Findings. Crit Rev Oncol Hematol. 2020 Jan;145:102831. doi: 10.1016/j.critrevonc.2019.102831. Epub 2019 Nov 13. PMID: 31783290; PMCID: PMC6982645.
Jones, M. R., Urits, I., Wolf, J., Corrigan, D., Colburn, L., Peterson, E., Williamson, A., & Viswanath, O. (2020). Drug-Induced Peripheral Neuropathy: A Narrative Review. Curr Clin Pharmacol, 15(1), 38-48. doi: 10.2174/1574884714666190121154813.
Jones, M. R., Urits, I., Wolf, J., Corrigan, D., Colburn, L., Peterson, E., Williamson, A., & Viswanath, O. (2020). Drug-Induced Peripheral Neuropathy: A Narrative Review. Current clinical pharmacology, 15(1), 38–48. https://doi.org/10.2174/1574884714666190121154813
Mellion, M., Gilchrist, J. M., Monte, S. (2011). Alcohol-related peripheral neuropathy: nutritional, toxic, or both?, Muscle Nerve, 43(3), 309-16. doi: 10.1002/mus.21946.
Monica, C., Narwastu, M., Irsan, A., & Fitriangga, A. (2021). Efektivitas penyuluhan terhadap tingkat pengetahuan mencuci tangan siswa MTs Miftahul Ulum 2 Kubu Raya. Jurnal Cerebellum, 6(4), 90–93. https://doi.org/10.26418/JC.V6I4.47738
Nakagawa, N., Yamamoto, S., Hanai, A., Oiwa, A., & Arao H. (2024). Exercise intervention for the management of chemotherapy-induced peripheral neuropathy: a systematic review and network meta-analysis. Front Neurol 15:1346099. doi: 10.3389/fneur.2024.1346099.
Pike, C. T., Birnbaum, H. G., Muehlenbein, C. E., Pohl, G. M., & Natale, R. B. (2012). Healthcare costs and workloss burden of patients with chemotherapy-associated peripheral neuropathy in breast, ovarian, head and neck, and nonsmall cell lung cancer. Chemotherapy Research and Practice, 1–10. https://doi.org/10.1155/2012/913848
Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., Macleod, M. R., Colvin, L. A., & Fallon, M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155(12), 2461–2470. https://doi.org/10.1016/J.PAIN.2014.09.020
Staff, N. P., Grisold, A., Grisold, W., & Windebank, A. J. (2017). Chemotherapy-induced peripheral neuropathy: A current review. Annals of Neurology, 81(6), 772–781. https://doi.org/10.1002/ANA.24951
Starobova, H., & Vetter, I. (2017). Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy. Frontiers in Molecular Neuroscience, 10. https://doi.org/10.3389/FNMOL.2017.00174
Windebank, A. J., & Grisold, W. (2008). Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System : JPNS, 13(1), 27–46. https://doi.org/10.1111/J.1529-8027.2008.00156.X
Zajączkowska, R., Kocot-Kępska, M., Leppert, W., Wrzosek, A., Mika, J., & Wordliczek, J. (2019). Mechanisms of Chemotherapy-Induced Peripheral Neuropathy. International journal of molecular sciences, 20(6), 1451. https://doi.org/10.3390/ijms20061451